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Melsa Manton (Barbara Stanwyck) is a wealthy Manhattan debutante who is notorious for headline grabbing pranks. One night, Melsa notices a man running out of a supposedly deserted house and goes to investigate. She discovers a body, but when the police eventually arrive the body has disappeared and Lieutenant Brent (Sam Levene) accuses Melsa of playing one of her jokes. High-flying newspaper reporter, Peter Ames (Henry Fonda), picks up the story and prints an article ridiculing the 'Park Avenue Pranksters'. But Melissa knows there is a killer on the loose and drags Ames all over Manhattan to find him in this manic comedy-thriller that saw the first ever pairing of Barbara Stanwyck and Henry Fonda.